Antibody drug conjugates (ADC)
Novoridge is dedicated to providing chemistry-focused antibody-drug conjugate (ADC) development services to the biotech and pharmaceutical industries. Our strong expertise lies in developing novel linker technologies and optimizing cytotoxic payload. Beyond offering high-quality novel linker technology and payload synthesis, we guide the selection of the most appropriate option based target’s biology. Our experts help identify a screening cascade that transitions from early discovery to a viable clinical candidate.
With our extensive knowledge in chemistry and ADCs, we can integrate various linker and payload technologies to enhance the clinical performance of the resulting bioconjugate. Being both as an advisor and a partner is core of our approach. Partnering with Novoridge, with our deep expertise in ADCs bioconjugation, and linker-payload technology can significantly accelerate your ADCs discovery research. Our scientific experts provide comprehensive and reliable support to empower our customers in advancing their research.Contact usto know more about how Novoridge can support your project and help you achieve your goals efficiently and cost-effectively.
Mechanism of antibody drug conjugates
Our ADC Services
ADC linker Development
We provide comprehensive services for designing and synthesizing ADC linkers and linker-drug conjugates as well as in-house linker library. Depending on the drug release mechanism and client's requirement, we create and produce a variety of ADC linkers, such as
- Redox sensitive cleavable linker
- Glutathione-sensitive: SPDB, (SPP)
- PH-sensitive: hydrazone
- Cathepsin B Cleavage Linkers
- Protease sensitae: vc, va
- Non-cleavable linker: mcc, mc, nhs
- PEG, Alkyl, peptide linkers
Antibody conjugation and Linker - Payload development
Novoridge can provide our customers according to their requirements, we design linkers that specifically bind via Lysine, Cysteine, or click chemistry conjugation and their cytotoxic payload optimization. With our extensive expertise in chemistry and ADCs, we can combine various linker and payload technologies to optimize the clinical performance of the bioconjugate.
Why is Novoridge the preferred choice for ADC services?
- Dedicated to developing innovative ADC technology based drug release mechanism, such as Redox sensitive cleavable and Cathepsin B Cleavage pathways
- Our expertise and dedicated team of experienced scientists
- Data analysis and detailed reports with results and discussion
- Highly reliable, and reproducible result
- Flexible and client-centric approach
- Efficient project management, rapid turn-around time, and competitive price
