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Radiochemistry

Expertise in radiopharmaceutical and theranostics precursors development

Support for precursor synthesis and reference compound

Radiochemistry

Lead optimization and 18F /11C precursor synthesis

Novoridge, a leading Chemistry CRO in radiopharmaceutical and theranostics precursors development services, supports accelerating your radiopharmaceuticals and theranostics drug development efforts. Contact us to know more about how Novoridge can support your project and help you achieve your goals efficiently and cost-effectively.

Novoridge
Novoridge

Theranostics Research

Theranostics = Therapeutics + Diagnostics

Theranostics combines the concepts of therapeutics and diagnostics. Radiotracer compound composed of radiation and chemical that selectively bind to specific targets in the body. It describes the combination of using one radioactive drug to identify (diagnose) a tumor and the second radioactive drug for delivery therapy to treat tumors.

Radiochemistry & Theranostics Services

Our team of experienced medicinal and radiochemistry experts is here to support the development of your project, whether it involves small molecules or peptides as diagnostic or therapeutic radiopharmaceuticals.

We offer comprehensive support from core design to focused library synthesis and lead optimization. For the most promising compounds, we also synthesize primary precursor compounds, utilizing optimized leaving/protecting group combinations to ensure high-yield radiolabeling reactions.Contact us to know more about how Novoridge can support your project and help you achieve your goals efficiently and cost-effectively.

Novoridge

Radiopharmaceutical & Theranostics precursor development

Target Identification Hit to Lead approaches Lead Discovery Lead Optimization Preclinical Studies
  • Virtual screening
  • De novo design
  • Machine learning approach Or Your Hit Target small molecules or peptides
  • Focused library design and synthesis
  • Design parameters for rational PET ligand Design
  • Understand the target (Bmax and bio-distribution)
  • Design core, focused library and synthesis
  • Structure handle for 18F or 11C labelling
  • Amenable for late-stage radiolabelling
  • Optimized protecting/leaving group for radiolabelling
  • Develop and synthesis precursor for radiolabelling
  • Synthesis reference standards

    Pharmacology

  • High Potency
  • High selectivity
  • PK properties

  • Brain permeability
  • Low non-specific binding (NSB)

Safe for clinical dosing and micro dosing GLP



Custom synthesis

  • Design and synthesis of small molecules for 11C or 18F precursor
  • Design and synthesis of peptide (e.g, PSMA, DOTA) linkers and precursor
  • Design and synthesis of iodine labelled linkers and precursor
  • Development of Boron labelled linkers and precursor